Detailed view for EmuJ_000900200

Basic information

TDR Targets ID: 956886
Echinococcus multilocularis, expressed conserved protein
Source Database / ID:  GeneDB

pI: 10.093 | Length (AA): 220 | MW (Da): 25161 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05071   NADH ubiquinone oxidoreductase subunit NDUFA12

Gene Ontology

Mouse over links to read term descriptions.
GO:0008137   NADH dehydrogenase (ubiquinone) activity  
GO:0016020   membrane  
GO:0009055   electron carrier activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_162739)

Species Accession Gene Product
Echinococcus granulosus EgrG_000900200   expressed conserved protein
Echinococcus granulosus EgrG_000900100   Ribosome binding protein 1
Echinococcus multilocularis EmuJ_000900100   Ribosome binding protein 1
Echinococcus multilocularis EmuJ_000900200   expressed conserved protein
Schistosoma japonicum Sjp_0311490   IPR007763,NADH:ubiquinone oxidoreductase 17.2 kD subunit,domain-containing
Schistosoma japonicum Sjp_0066150   IPR009053,Prefoldin;IPR010978,tRNA-binding arm;IPR010989,t-snare,domain-containing
Schistosoma mansoni Smp_171540.1   Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp)
Schistosoma mansoni Smp_171540.3   Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp)
Schistosoma mansoni Smp_171550   hypothetical protein
Schistosoma mansoni Smp_171540.2   Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp)
Schmidtea mediterranea mk4.003446.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000900200 (Echinococcus multilocularis), expressed conserved protein
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